What question did this study set out to answer?

To determine whether pulmonary gas exchange limitations constrain VO2max in highly trained athletes who experience exercise-induced hypoxemia.

June 1, 1989Journal of Applied Physiology

Effects of incomplete pulmonary gas exchange on VO2 max

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Why the study?

Does mild hyperoxia improve VO2max in highly trained athletes with exercise-induced hypoxemia compared to normoxia?

Population

20 healthy male volunteers divided into trained and highly trained with exercise-induced hypoxemia.

Comparison

Mild hyperoxic conditions during an incremental… vs Normoxic conditions at sea level during an…

Design

Other

Authors

SPScott K. PowersScottish Power (United Kingdom)JLJames V. LawlerUniversity of Nebraska Medical Center JDJerome A. DempseyUniversity College Dublin

Discussion

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Implication

Hyperoxia may selectively raise VO2max in highly trained athletes; hypothesis-generating and should not yet change training practice.

Key Points

To determine whether pulmonary gas exchange limitations constrain VO2max in highly trained athletes who experience exercise-induced hypoxemia.
Divided 20 healthy male volunteers into trained (T; n = 13, mean VO2max = 56.5 ml·kg⁻¹·min⁻¹) and highly trained (HT; n = 7, mean VO2max = 70.1 ml·kg⁻¹·min⁻¹, exercise %SaO2 ≤ 92%) groups.
Subjects completed incremental cycle ergometer exercise tests at sea level under normoxic (21% O2) and mild hyperoxic (26% O2) conditions to measure VO2max and %SaO2.
Maximal exercise mean %SaO2 was significantly higher under hyperoxia than normoxia in both the T group (96.1% vs. 94.1%, P < 0.05) and the HT group (95.9% vs. 90.6%, P < 0.05).
Hyperoxia significantly elevated mean VO2max in the HT group compared with normoxia (74.7 vs. 70.1 ml·kg⁻¹·min⁻¹, P < 0.05), but produced no difference in the T group (57.1 vs. 56.5 ml·kg⁻¹·min⁻¹).

Structured PICO

Does mild hyperoxia improve VO2max in highly trained athletes with exercise-induced hypoxemia compared to normoxia?

Population

20 healthy male volunteers divided into trained (n=13, mean VO2max 56.5 ml.kg-1.min-1) and highly trained with exercise-induced hypoxemia (n=7, mean VO2max 70.1 ml.kg-1.min-1, %SaO2 ≤92%).

Intervention

Mild hyperoxic conditions (26% O2) during an incremental cycle ergometer exercise test

Comparator

Normoxic conditions (21% O2) at sea level during an incremental cycle ergometer exercise test

Outcome

VO2max and percentage of O2 bound to hemoglobin (%SaO2) during maximal exercisesurrogate

Pulmonary gas exchange limitations may restrict VO2max in highly trained athletes who exhibit exercise-induced hypoxemia at sea level.

Cite This Study

Powers et al. (1989) studied this question.

synapsesocial.com/papers/6a6f904ff44fa9f079dd0485 https://doi.org/10.1152/jappl.1989.66.6.2491

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Effects of incomplete pulmonary gas exchange on VO2 max

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of incomplete pulmonary gas exchange on VO2 max

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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