What question did this study set out to answer?

To review evidence evaluating the role of human herpesvirus 6B (HHV-6B) infection in prolonged febrile seizures and the subsequent pathogenesis of mesial temporal sclerosis.

July 9, 2008EpilepsiaOpen Access

Human herpes virus 6B: A possible role in epilepsy?

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Authors

WTWilliam H. TheodoreNational Institutes of Health LELeon G. EpsteinRutgers, The State University of New Jersey WGWilliam D. GaillardGeorge Washington University Hospital

Discussion

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Implication

Review highlights human herpesvirus 6B replication in hippocampal astrocytes among mesial temporal sclerosis patients, suggesting viral involvement in intractable temporal lobe epilepsy.

Key Points

To review evidence evaluating the role of human herpesvirus 6B (HHV-6B) infection in prolonged febrile seizures and the subsequent pathogenesis of mesial temporal sclerosis.
Synthesized findings from clinical cohorts and an ongoing multicenter study examining connections between HHV-6 infection, febrile status epilepticus, and mesial temporal sclerosis (MTS).
Assessed virological and molecular assays conducted on resected surgical temporal lobectomy specimens from patients with MTS versus non-MTS epilepsy controls.
Active viral replication of HHV-6B, but not HHV-6A, was detected in hippocampal astrocytes in approximately two-thirds of resected tissue specimens from patients with mesial temporal sclerosis, while remaining absent in other epilepsy etiologies.
Impairment of astrocyte excitatory amino acid transport by active HHV-6B replication was identified as a candidate mechanism promoting excitotoxic neuronal injury and epileptogenesis.

Cite This Study

Theodore et al. (2008) studied this question.

synapsesocial.com/papers/6a6f9126febe604dd7087657 https://doi.org/10.1111/j.1528-1167.2008.01699.x

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Implication

Review highlights human herpesvirus 6B replication in hippocampal astrocytes among mesial temporal sclerosis patients, suggesting viral involvement in intractable temporal lobe epilepsy.

Human herpes virus 6B: A possible role in epilepsy?

Discussion

Member takes

Implication

Key Points

Cite This Study

Human herpes virus 6B: A possible role in epilepsy?

Discussion

Member takes

Implication

Key Points

Cite This Study

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