Population
Isolated rat aortic rings (with intact or denuded endothelium)
Design
Preclinical
Authors
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Extends AT2-bradykinin-NO mechanisms in rodent vessels; leaves open translation to human vascular tone or therapy.
High concentrations of angiotensin II induce endothelium-independent vasorelaxation in rat aorta via AT2 receptors, bradykinin B2 receptors, and downstream NO-cGMP and K+ channel activation.
Fukada et al. (2005) studied this question.