Why the study?
Does AT2 receptor stimulation cause vasodilation through local production of bradykinin in rat mesenteric arteries?
Population
Pressurized and perfused rat mesenteric arterial segments from normal wild-type Brown Norway rats and…
Comparison
Perfusion of angiotensin II in the presence of… vs Normal wild-type rats vs kininogen-deficient…
Design
Preclinical
Authors
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Confirms bradykinin mediation of AT2 vasodilation in rat vessels; leaves open translation to humans and any therapeutic relevance.
Does AT2 receptor stimulation cause vasodilation through local production of bradykinin in rat mesenteric arteries?
AT2 receptor stimulation causes vasodilation through local production of bradykinin in a flow-dependent manner, counterbalancing AT1-dependent vasoconstriction.
Katada et al. (2002) studied this question.
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