Why the study?
Does nitric oxide synthase inhibition with L-NAME affect vascular tone and arterial pressure differently in pregnant versus non-pregnant rabbits?
Population
Anaesthetized, acutely instrumented non-pregnant and late pregnant New Zealand white rabbits
Comparison
L-NAME (N-nitro-L-arginine methyl ester) 1, 10… vs Baseline and comparison between non-pregnant and…
Design
Preclinical
Authors
Loading...
Indicates NO-independent mechanisms sustain low vascular tone in pregnant rabbits; leaves open relevance to human gestational hemodynamics.
Does nitric oxide synthase inhibition with L-NAME affect vascular tone and arterial pressure differently in pregnant versus non-pregnant rabbits?
The study suggests that the low vascular tone and arterial pressure observed in pregnant rabbits is not mediated by nitric oxide.
Losonczy et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: