August 5, 2009Biochemical Journal

Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle

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Population

Cultured rat vascular smooth muscle cells (VSMCs), primary human VSMCs, and isolated rat aortic segments

Design

Preclinical

Follow-up

7 days (for isolated rat aortic segments)

Authors

BRBenjamin S. RaynerCancer Institute of New South Wales SHSusan HuaHunter Medical Research Institute TSTharani SabaretnamMacquarie University

Discussion

Member takes

Implication

Should not change practice; leaves open a feedback role for myoglobin in vascular NO homeostasis.

Structured PICO

Population

Cultured rat vascular smooth muscle cells (VSMCs), primary human VSMCs, and isolated rat aortic segments

Intervention

Nitric oxide (*NO) donors (diethylamineNONOate or spermineNONOate) at cumulative doses (0.1, 1 or 10 microM) or L-arginine

Outcome

Myoglobin (Mb) gene and protein expressionsurrogate

Nitric oxide upregulates myoglobin expression in vascular smooth muscle cells, suggesting a feedback mechanism regulating NO concentration in the vessel wall.

Cite This Study

Rayner et al. (2009) studied this question.

synapsesocial.com/papers/6a6f92c2439bab0cabc2d7db https://doi.org/10.1042/bj20090716

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Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider