What question did this study set out to answer?

Determine whether trans,trans-muconic acid is a genuine in vivo metabolite of benzene and clarify the role of cis isomers in its metabolic formation.

June 1, 1952Biochemical JournalOpen Access

The separation of esters of choline by filter-paper chromatography

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Biochemical analysis reveals trans,trans-muconic acid as a direct benzene metabolite in vivo, suggesting cis isomers are not necessary intermediates.

Determine whether trans,trans-muconic acid is a genuine in vivo metabolite of benzene and clarify the role of cis isomers in its metabolic formation.
Evaluated the metabolic pathway of benzene and related dicarboxylic acids in animal systems.
Assessed the in vivo interconversion between cis,cis and trans,trans stereoisomers of muconic acid.
Identified trans,trans-muconic acid as a true biological metabolite of benzene rather than a derivative formed in vivo from cis,cis-muconic acid.
Determined that cis,cis-muconic acid does not serve as an obligatory metabolic intermediate in the synthesis of the trans,trans isomer within the animal body.

Whittaker et al. (1952) studied this question.

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Biochemical analysis reveals trans,trans-muconic acid as a direct benzene metabolite in vivo, suggesting cis isomers are not necessary intermediates.