What question did this study set out to answer?

To evaluate the efficacy of prophylactic low-dose oral propranolol in reducing clinically significant supraventricular tachyarrhythmias following coronary artery bypass surgery.

August 1, 1988The Thoracic and Cardiovascular Surgeon

Supraventricular Tachyarrhythmias After Coronary Bypass Surgery - A Double Blind Randomized Trial of Prophylactic Low Dose Propranolol

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Why the study?

Does prophylactic low-dose propranolol reduce clinically important supraventricular tachyarrhythmias in patients after coronary artery bypass surgery?

Population

75 patients after coronary artery bypass surgery

Comparison

Propranolol 10 mg orally 4 times a day vs Placebo

Design

RCT, randomized, double blind

Follow-up

4 postoperative days

Authors

HMH. J. MartinussenUppsala University ALAnnette LolkUniversity of Southern Denmark CSCezary SzczepańskiŁukasiewicz Research Network - Institute of Aviation

Discussion

Member takes

Implication

Prophylactic low-dose propranolol does not reduce post-CABG supraventricular tachyarrhythmias; challenges routine use and directs research toward alternative strategies.

Key Points

To evaluate the efficacy of prophylactic low-dose oral propranolol in reducing clinically significant supraventricular tachyarrhythmias following coronary artery bypass surgery.
Conducted a double-blind randomized trial in 75 patients undergoing coronary artery bypass surgery.
Randomly assigned patients to receive either oral propranolol 10 mg four times daily (n=35) or placebo (n=40).
Monitored and recorded clinically important supraventricular tachyarrhythmias over the first 4 postoperative days.
Supraventricular tachyarrhythmias occurred in 5 of 35 patients (14.3%) receiving propranolol and in 5 of 40 patients (12.5%) receiving placebo, with no statistically significant difference.

Structured PICO

Does prophylactic low-dose propranolol reduce clinically important supraventricular tachyarrhythmias in patients after coronary artery bypass surgery?

Population

75 patients after coronary artery bypass surgery

Intervention

Propranolol 10 mg orally 4 times a day

Comparator

Placebo

Outcome

Episodes of clinically important supraventricular tachyarrhythmias in the first 4 postoperative dayshard clinical

Prophylactic low-dose propranolol did not significantly reduce the frequency of supraventricular tachyarrhythmias in the early postoperative period after coronary artery bypass surgery.

Cite This Study

Martinussen et al. (1988) studied this question.

synapsesocial.com/papers/6a6f93052fdcb5703edb4acb https://doi.org/10.1055/s-2007-1020079

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Implication

Prophylactic low-dose propranolol does not reduce post-CABG supraventricular tachyarrhythmias; challenges routine use and directs research toward alternative strategies.

Supraventricular Tachyarrhythmias After Coronary Bypass Surgery - A Double Blind Randomized Trial of Prophylactic Low Dose Propranolol

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Supraventricular Tachyarrhythmias After Coronary Bypass Surgery - A Double Blind Randomized Trial of Prophylactic Low Dose Propranolol

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider