Key result
Low-dose propranolol significantly reduced supraventricular tachyarrhythmias compared to control (7% vs 35%, P<0.05) after coronary artery bypass grafting, whereas diltiazem was ineffective.
Why the study?
Does prophylactic low-dose propranolol or diltiazem reduce the occurrence of supraventricular tachyarrhythmia in patients after coronary artery bypass grafting?
Population
103 consecutive patients undergoing coronary artery bypass grafting (CABG)
Comparison
Propranolol 10 mg every 6 h postoperatively… vs Diltiazem 0.1 mg/kg per h i.v. or a control group
Design
RCT, randomized prospectively into three groups
Follow-up
3 days postoperatively
Authors
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Propranolol prophylaxis warrants consideration after CABG; confirms beta-blocker efficacy and challenges diltiazem in arrhythmia prevention.
RCT (n=103)
prospective
Does prophylactic low-dose propranolol or diltiazem reduce the occurrence of supraventricular tachyarrhythmia in patients after coronary artery bypass grafting?
Absolute Event Rate: 7% vs 35%
p-value: p=< 0.05
Low-dose propranolol is an effective and safe prophylaxis for preventing supraventricular tachyarrhythmias after CABG, whereas diltiazem is ineffective and increases the need for inotropic support.
Babin-Ebell et al. (1996) conducted an RCT in Supraventricular tachyarrhythmia after coronary artery bypass grafting (n=103). Propranolol or Diltiazem vs. Control group was evaluated on Occurrence of supraventricular tachyarrhythmias (SVT) (p=< 0.05). Low-dose propranolol significantly reduced supraventricular tachyarrhythmias compared to control (7% vs 35%, P<0.05) after coronary artery bypass grafting, whereas diltiazem was ineffective.
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