Natulan (Procarbazine) combined with radiotherapy in management of inoperable malignant melanoma.

the malignant cases multiple metastases were verified at the time of surgery.Homovanillic acid determination was by a modified fluorometric assay (Sato, 1965).As shown in the Table, the only finding of abnormality was a slightly increased homo- vanillic acid in one of the malignant cases.It may certainly be concluded that the absence of elevated homovanillic acid does not rule out the possibility of a malig- nant tumour.Contrariwise, the presence of an increased urinary homovanilhic acid does not necessarily indicate malig- nancy, though available data suggest this finding may be more common in malignant than in benign cases.