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The Rye Conference histologic classification of Hodgkin's disease has been applied retrospectively to a series of 176 previously untreated cases of Hodgkin's disease. Three different pathologists independently and unanimously agreed in two-thirds of the cases on assignment of cases to one of the four categories: lymphocyte predominance, nodular sclerosis, mixed cellularity, and lymphocyte depletion. The classification was found to be effective in predicting prognosis even within clinical staging groups. Nodular sclerosis emerges as the largest histologic group and has a favorable prognosis. The usual manner of spread in Hodgkin's disease was to adjacent lymph node groups. Noncontiguous dissemination, when it occurred, was more than twice as frequent in the mixed cellularity and lymphocyte depletion types, compared to nodular sclerosis. Nodular sclerosis involving lung has shown a favorable prognosis, unlike mixed cellularity. Survival appears to be increased in all histologic categories after intensive wide-field megavoltage radiotherapy.
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Keller et al. (1968) studied this question.
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