October 30, 2018Frontiers in PharmacologyOpen Access

Appropriateness of DOAC Prescribing Before and During Hospital Admission and Analysis of Determinants for Inappropriate Prescribing

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Population

772 hospitalized patients aged ≥60 years with at least one direct oral anticoagulant intake during hospital…

Design

Cohort

Authors

Discussion

Inappropriate DOAC dosing in older inpatients warrants prescribing review; leaves open questions on outcomes and optimal guideline use.

Population

772 hospitalized patients aged ≥60 years with at least one direct oral anticoagulant (DOAC) intake during hospital stay

Intervention

Direct oral anticoagulants (DOACs: dabigatran, rivaroxaban, apixaban)

Outcome

Appropriateness of DOAC dosing according to the summaries of product characteristics (SmPC) and determinants for inappropriate prescribing

Inappropriate DOAC prescribing is frequent among hospitalized older adults, with underdosing being the most common error, particularly for apixaban.

Moudallel et al. (2018) studied this question.

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