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March 17, 2015PLoS ONEOpen Access

External Validation of Fatty Liver Index for Identifying Ultrasonographic Fatty Liver in a Large-Scale Cross-Sectional Study in Taiwan

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Why the study?

Does the Fatty Liver Index accurately identify ultrasonographic fatty liver in a Taiwanese population?

Population

29,797 consecutive subjects receiving health check-up services at Taipei Veterans General Hospital from 2002…

Comparison

Fatty Liver Index calculated using… vs Other non-invasive markers including lipid…

Design

Cross-sectional

Authors

BYBi-Ling YangCheng Hsin General HospitalWWWen-Chieh WuNational Yang Ming Chiao Tung UniversityKFKuan‐Chieh FangPingtung Hospital

Discussion

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Overview

Supports FLI screening in East Asians; extends validation beyond Western cohorts but leaves optimal cutoffs and prospective utility open.

Structured PICO

Does the Fatty Liver Index accurately identify ultrasonographic fatty liver in a Taiwanese population?

P
Population
29,797 consecutive subjects receiving health check-up services at Taipei Veterans General Hospital from 2002 to 2009, mean age 52.2 years, 54.0% male. Excluded: chronic HCV, chronic HBV, and dual HBV/HCV infections.
I
Intervention
Fatty Liver Index (FLI) calculated using triglycerides, BMI, GGT, and waist circumference
C
Comparator
Other non-invasive markers including lipid accumulation products (LAP), BMI, waist circumference, ALT, GGT, fasting glucose, cholesterol, TG, HDL, and LDL
O
Outcome
Ability of the FLI to detect ultrasonographic fatty liver assessed by area under the receiver operating characteristic (AUROC) curvesurrogate

The Fatty Liver Index accurately identifies ultrasonographic fatty liver in a Taiwanese population, though optimal cut-off values are lower than those for Western populations.

Cite This Study

Yang et al. (2015) studied this question.

synapsesocial.com/papers/6a6f948ca528af2d65c310cchttps://doi.org/10.1371/journal.pone.0120443
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