Population
Fetal and adult cardiomyocytes
Design
Review
Authors
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Informs age-specific Ca2+ handling models in cardiology; extends developmental physiology understanding but leaves clinical translation open.
This review highlights the developmental changes in excitation-contraction coupling in cardiomyocytes, emphasizing the transition from fetal Ca2+ influx mechanisms to adult Ca2+ spark generation.
Tohse et al. (2004) studied this question.
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