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Describes the established mechanism of excitation-contraction coupling in cardiac myocytes via calcium-induced calcium release.
It is well established that excitation contraction (EC) coupling in cardiac myocytes is mediated by the entry of calcium ions (Ca2+) from the bathing medium into the cell cytoplasm ([Fabiato, 1985][1]), which then triggers calcium-induced calcium release (CICR) from the sarcoplasmic reticulum (SR).
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Balke et al. (2003) studied this question.
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