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January 1, 1988Thrombosis and HaemostasisOpen Access

Plasma Collagen Cofactor Correlates with von Willebrand Factor Antigen and Ristocetin Cofactor but Not with Bleeding Time

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Population

Plasma from normal individuals and individuals with von Willebrand's disease (vWD)

Design

Preclinical

Authors

MAMorio AiharaHirosaki UniversityAKAsano KIMURAYCYoichi ChibaKagawa University

Discussion

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Implication

CCo may complement vWF assays in preclinical research; leaves open clinical utility and human validation.

Structured PICO

P
Population
Plasma from normal individuals and individuals with von Willebrand's disease (vWD)
I
Intervention
Measurement of Collagen cofactor (CCo) activity and its inhibition by monoclonal antibodies (CLB-RAg 201 and CLB-RAg 35)
O
Outcome
Correlation of CCo with vWF antigen (vWF:Ag), ristocetin cofactor (RCo), factor VIII coagulant activity (VIII:C), and quantitative bleeding timesurrogate

Collagen cofactor is a functional activity of von Willebrand factor that correlates with other vWF markers but not bleeding time, and its measurement may help detect variant forms of von Willebrand's disease.

Cite This Study

Aihara et al. (1988) studied this question.

synapsesocial.com/papers/6a6f98c1660549caf2c421cehttps://doi.org/10.1055/s-0038-1647520
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Also Consider

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  1. 1Von Willebrand Factor Collagen-Binding Activity and Von Willebrand Factor-Mediated Platelet Adhesion in Patients with Coronary Artery Disease2024 · 1 citations
  2. 2Contribution of the collagen binding activity (VWF:CB) in the range of tests for the diagnosis and classification of von Willebrand disease2015 · 4 citations
  3. 3In vitro Evaluation of a Very‐High‐Purity, Solvent/Detergent‐Treated, Von Willebrand Factor Concentrate1991 · 23 citations
  4. 4A Reliable von Willebrand Factor: Ristocetin Cofactor Enzyme-Linked Immunosorbent Assay to Differentiate between Type 1 and Type 2 von Willebrand Disease2002 · 17 citations
  5. 5Evaluation of an automated platelet-based assay of ristocetin cofactor activity2010 · 20 citations