Key result
The VWF:CB test showed good correlation with VWF:RCo for all VWD types except type 2 and good concordance with multimer pattern, serving as an alternative for diagnosing quantitative VWF deficiencies.
Why the study?
Does the VWF collagen binding test (VWF:CB) improve the diagnosis and classification of von Willebrand disease compared to VWF:RCo and multimer pattern in patients with recurrent bleeding?
Population
19 patients suffering from recurrent bleeding
Comparison
von Willebrand factor collagen binding test vs VWF risticetin cofactor activity and multimer…
Design
Cross-sectional
Authors
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Supports VWF:CB as alternative for quantitative VWD diagnosis; leaves open utility in type 2 and routine classification.
Observational (n=19)
Does the VWF collagen binding test (VWF:CB) improve the diagnosis and classification of von Willebrand disease compared to VWF:RCo and multimer pattern in patients with recurrent bleeding?
VWF:CB is a viable alternative to VWF:RCo and multimer pattern for diagnosing quantitative VWF deficiencies, though it does not replace qualitative defect testing.
Ferhat-Hamida et al. (2015) conducted an observational in von Willebrand disease (n=19). von Willebrand factor collagen binding test (VWF:CB) vs. VWF risticetin cofactor (VWF:RCo) and multimer pattern was evaluated on Diagnosis and classification of VWD subtypes. The VWF:CB test showed good correlation with VWF:RCo for all VWD types except type 2 and good concordance with multimer pattern, serving as an alternative for diagnosing quantitative VWF deficiencies.
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