Why the study?
Do commercial VWF:CB assays accurately discriminate between types 1 and 2 von Willebrand disease compared to in-house reference assays?
Population
Samples from 25 patients with type 1 von Willebrand disease of varying severity, 16 samples from patients…
Comparison
Seven commercial von Willebrand factor collagen… vs Standard in-house VWF:CB assay, in-house VWF…
Design
Cross-sectional
Authors
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Assay variability may limit reliable VWD subtyping; leaves open need for standardization before clinical use.
Do commercial VWF:CB assays accurately discriminate between types 1 and 2 von Willebrand disease compared to in-house reference assays?
Commercial VWF:CB assays exhibit variability in discriminating VWD types and require further standardization before widespread diagnostic use.
Emmanuel J. Favaloro (2010) studied this question.
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