Population
Blood samples (serum, plasma, filtered plasma) and fractionated normal plasma VWF
Comparison
Evaluation using ELISA-based collagen-VWF… vs Standard antigen assay and standard…
Design
Preclinical
Authors
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Sample handling errors may mimic Type 2 VWD; animal data leave open VWF:CBA adoption in clinical testing.
The VWF:CBA assay is more sensitive to high molecular weight forms of VWF, highlighting that inappropriate sample preparation (e.g., filtered plasma or serum) can lead to false diagnoses of Type 2A or 2B von Willebrand's disease.
Favaloro et al. (1995) studied this question.
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