Why the study?
Does the von Willebrand Factor Collagen-Binding (Activity) Assay (vWF:CBA) improve the diagnosis and classification of von Willebrand disease compared to other functional assays?
Population
Patients with or suspected of having von Willebrand disease (vWD)
Comparison
von Willebrand Factor Collagen-Binding Assay vs vWF ristocetin cofactor activity and vWF antigen
Design
Review
Authors
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Supports vWF:CBA incorporation into vWD diagnostic panels; leaves open prospective standardization trials before routine adoption.
Does the von Willebrand Factor Collagen-Binding (Activity) Assay (vWF:CBA) improve the diagnosis and classification of von Willebrand disease compared to other functional assays?
The vWF:CBA is a superior functional screening test for detecting high-molecular-weight vWF forms, aiding in the accurate diagnosis and classification of von Willebrand disease subtypes.
Emmanuel J. Favaloro (2002) studied this question.
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