Why the study?
Increasing attention is being paid to qualitative characteristics of von Willebrand factor alongside quantitative measures in von Willebrand disease.
Does the measurement of vWF:CBAI and vWF:CBAIII improve the diagnostic distinction between healthy individuals and patients with type 1 von Willebrand disease?
Population
224 female patients with previously diagnosed type 1 vWD and 80 healthy female donors
Comparison
Type 1 vWD patients vs healthy blood donors
Design
Prospective study
Authors
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vWF collagen-binding assays may refine type 1 vWD subtyping; leaves open routine diagnostic adoption pending confirmatory studies.
Does the measurement of vWF:CBAI and vWF:CBAIII improve the diagnostic distinction between healthy individuals and patients with type 1 von Willebrand disease?
Testing for vWF binding capacity to collagen types I and III may serve as a useful additional diagnostic tool to distinguish patients with type 1 von Willebrand disease from healthy individuals.
Колосков et al. (2023) studied this question.
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