Why the study?
Does an automated platelet-based assay improve sensitivity and precision compared to standard aggregometry for measuring ristocetin cofactor activity in patients with von Willebrand's disease?
Population
134 subjects, comprising 65 healthy normal subjects and 69 patients with von Willebrand's disease evaluated…
Comparison
Automated assay using a combined fixed… vs Standard aggregometry using lyophilised fixed…
Design
Other
Authors
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May enhance low-level VWF:RCo detection in vWD; leaves open whether automated assay replaces aggregometry pending validation.
Does an automated platelet-based assay improve sensitivity and precision compared to standard aggregometry for measuring ristocetin cofactor activity in patients with von Willebrand's disease?
An automated VWF:RCo assay offers a more sensitive, reproducible, and robust alternative to standard aggregometry for evaluating von Willebrand factor activity.
Lawrie et al. (2010) studied this question.
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