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July 27, 2019Prenatal DiagnosisOpen Access

Transposition of the great arteries: Fetal pulmonary valve growth and postoperative neo‐aortic root dilatation

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Why the study?

To document semilunar valve growth in fetal transposition of the great arteries and evaluate the relationship between prenatal pulmonary valve annulus dimensions and postoperative neo-aortic root dilatation.

Does prenatal pulmonary valve annulus dimension correlate with postoperative neo-aortic root dilatation in fetuses with transposition of the great arteries undergoing arterial switch operation?

Population

137 TGA fetuses suitable for ASO

Comparison

TGA semilunar valve annulus trends vs normal control values

Design

Retrospective multicenter observational study

Authors

RPRoel L.F. van der PalenCZCarlijn van der ZeeAVArja S. Vink

Discussion

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Overview

Observational TGA data link prenatal PV size to post-ASO NAoR dilatation; leaves open whether fetal monitoring alters reintervention risk or counseling.

Structured PICO

Does prenatal pulmonary valve annulus dimension correlate with postoperative neo-aortic root dilatation in fetuses with transposition of the great arteries undergoing arterial switch operation?

P
Population
137 fetuses with transposition of the great arteries (TGA) suitable for arterial switch operation (ASO), 35.8% with significant ventricular septal defects (VSDs). 121 underwent ASO.
I
Intervention
Measurement of prenatal semilunar valve annuli and postoperative neo-aortic root (NAoR) diameters following arterial switch operation (ASO)
C
Comparator
Normal control values for aortic and pulmonary valve annuli
O
Outcome
Trends in annulus diameters and correlation between prenatal semilunar valve Z-scores and postoperative neo-aortic root (NAoR) diameterssurrogate

Fetal TGA semilunar valve annuli are larger than normal, and prenatal pulmonary valve dimensions correlate significantly with postoperative neo-aortic root dilatation, suggesting fetal anatomy influences late reintervention risk.

Cite This Study

Palen et al. (2019) studied this question.

synapsesocial.com/papers/6a6f98f435aa2c282ce0f0d0https://doi.org/10.1002/pd.5539
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neo-aortic valvar function after the arterial switch2006 · 84 citations
  2. 2Development of <i>Z</i>‐scores for fetal cardiac dimensions from echocardiography2005 · 314 citations
  3. 3Reoperation for neoaortic root pathology after the arterial switch operation2014 · 49 citations
  4. 4Persistent neo-aortic growth during adulthood in patients after an arterial switch operation2014 · 32 citations