Key result
Fetuses with TGA-IVS exhibited higher global pulmonary flow, lower ductal flow, and a smaller foramen ovale at 28-32 and 35-38 weeks' gestation compared with normal fetuses.
Why the study?
Little was known about cardiac hemodynamics in fetuses with transposition of the great arteries and intact ventricular septum (TGA-IVS), and better understanding could provide insights into neonatal hypoxia and pulmonary hypertension.
Cohort (n=219)
No
Fetuses with TGA-IVS undergo complex blood flow redistribution during the second half of pregnancy, which is associated with lower postnatal oxygen saturation and may explain premature foramen ovale closure and postnatal hypoxia.
No takes yet. Share an insight, caveat, or question.
May support closer fetal surveillance for hypoxia risk in TGA-IVS; leaves open need for prospective outcome studies.
Lachaud et al. (2019) conducted a cohort in Transposition of the great arteries and intact ventricular septum (TGA-IVS) (n=219). Transposition of the great arteries and intact ventricular septum (TGA-IVS) vs. Normal fetuses was evaluated on Cardiac hemodynamics (global cardiac output, aortic flow, ductal flow, foramen ovale diameter). Fetuses with TGA-IVS exhibited higher global pulmonary flow, lower ductal flow, and a smaller foramen ovale at 28-32 and 35-38 weeks' gestation compared with normal fetuses.
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