November 22, 2016Ultrasound in Obstetrics and GynecologyOpen Access

Cardiac output and blood flow redistribution in fetuses with D‐loop transposition of the great arteries and intact ventricular septum: insights into pathophysiology

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Why the study?

Does D-TGA/IVS alter cardiac valve sizes, ventricular contribution to CVO, and shunt flow direction in fetuses compared to normal controls?

Population

74 fetuses with D-loop transposition of the great arteries and intact ventricular septum and 222…

Design

Cohort

Authors

MGMax GodfreyNewcastle College KFKevin G. FriedmanBoston University MDMonika DrogoszRhode Island Department of Health

Discussion

Member takes

Implication

Altered fetal hemodynamics in D-TGA/IVS warrant attention in prenatal imaging; leaves open whether these patterns predict postnatal outcomes.

Structured PICO

Does D-TGA/IVS alter cardiac valve sizes, ventricular contribution to CVO, and shunt flow direction in fetuses compared to normal controls?

Population

74 fetuses with D-loop transposition of the great arteries and intact ventricular septum (D-TGA/IVS) and 222 gestational-age matched normal controls

Comparator

Normal fetuses matched for gestational-age range

Outcome

Ventricular contribution to combined ventricular output (CVO), cardiac valve sizes (aortic, pulmonary, mitral, and tricuspid valves), and direction of flow at the foramen ovale (FO) and ductus arteriosus (DA)surrogate

Fetuses with D-TGA/IVS exhibit a loss of normal right-sided dominance, with each ventricle providing half of the combined ventricular output and a high incidence of bidirectional shunting at the foramen ovale and ductus arteriosus.

Cite This Study

Godfrey et al. (2016) studied this question.

synapsesocial.com/papers/6a7e9efaa390b11a0aa6c480 https://doi.org/10.1002/uog.17370

Topics

Echocardiography

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Implication

Altered fetal hemodynamics in D-TGA/IVS warrant attention in prenatal imaging; leaves open whether these patterns predict postnatal outcomes.

Cardiac output and blood flow redistribution in fetuses with D‐loop transposition of the great arteries and intact ventricular septum: insights into pathophysiology

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Cardiac output and blood flow redistribution in fetuses with D‐loop transposition of the great arteries and intact ventricular septum: insights into pathophysiology

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider