Why the study?
Does phenylephrine alter systemic and cerebral hemodynamics and oxygenation in humans?
Population
Humans (awake and anaesthetised)
Comparison
Phenylephrine administration
Design
Systematic review
Authors
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Phenylephrine may impair cerebral oxygenation despite raising BP and CBF; extends evidence of CO-flow mismatch to brain tissue monitoring.
Does phenylephrine alter systemic and cerebral hemodynamics and oxygenation in humans?
Phenylephrine administration increases blood pressure and cerebral blood flow but paradoxically reduces cardiac output and cerebral tissue oxygen saturation, highlighting the need for careful monitoring in acute care.
Meng et al. (2023) studied this question.
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