May 25, 2004AJP Regulatory Integrative and Comparative Physiology

Effects of age on brachial artery myogenic responses in humans

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Why the study?

Does aging affect brachial artery myogenic responses to changes in transmural pressure in humans?

Population

24 subjects, comprising 12 younger men and women and 12 older men and women, matched for gender and body…

Comparison

Alteration of forearm transmural pressure. vs Comparison between older and younger subjects.

Design

Cross-sectional

Authors

MLMary E. J. LottPennsylvania State University MHMichael D. HerrPennsylvania State University LSLawrence I. SinowayGeneral Cardiology

Discussion

Member takes

Implication

May reflect age-related myogenic impairment in resistance vessels; leaves open clinical relevance and need for longitudinal or interventional studies.

Structured PICO

Does aging affect brachial artery myogenic responses to changes in transmural pressure in humans?

Population

24 subjects, comprising 12 younger men and women (mean age 25 +/- 1 yr) and 12 older men and women (mean age 65 +/- 1 yr), matched for gender and body composition.

Intervention

Alteration of forearm transmural pressure (raising or lowering by 50 mmHg within 0.2 s using a specially designed tank).

Comparator

Comparison between older and younger subjects.

Outcome

Mean blood velocity (MBV) in the brachial artery in response to changes in transmural pressure.surrogate

Aging impairs dynamic vasoconstriction and alters myogenic responses to changes in transmural pressure in the human brachial artery.

Cite This Study

Lott et al. (2004) studied this question.

synapsesocial.com/papers/6a6f99b078a11c550e09539e https://doi.org/10.1152/ajpregu.00612.2003

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Implication

May reflect age-related myogenic impairment in resistance vessels; leaves open clinical relevance and need for longitudinal or interventional studies.