August 1, 1985Circulation
Accuracy of volume measurement by conductance catheter in isolated, ejecting canine hearts.
Population
Six isolated, ejecting, canine left ventricles
Comparison
Intraventricular volume measurement by… vs Direct volume measurement by a validated…
Design
Preclinical
Authors
Discussion
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Implication
Supports conductance catheter validation in isolated hearts; leaves open translation to in vivo human use.
Key Points
- This study aims to assess the accuracy of measuring intraventricular volume using conductance catheter technique in isolated canine hearts.
- Left ventricular volumes were measured using a validated servosystem with an electroconductive balloon.
- Hearts were simulated to eject and fill physiologically with a computer-simulated arterial loading system.
- The relationship between balloon volume (Vbal) and conductance volume (Vcath) was analyzed, considering influenced right ventricular volumes.
- There was a strong linear correlation between Vbal and Vcath with r² = 0.982 ± 0.014.
- The equation was established: Vcath = 0.82 (± 0.05) Vbal + 26.7 (± 11.8) ml.
- Right ventricular volume had minimal effect, shifting the relationship by less than 3 ml.
Structured PICO
P
Population
Six isolated, ejecting, canine left ventricles
I
Intervention
Intraventricular volume measurement by intracavitary electrical conductance (conductance catheter method)
C
Comparator
Direct volume measurement by a validated servosystem using an electroconductive balloon (Vbal)
O
Outcome
Accuracy and linearity of volume measurement (relationship between Vbal and Vcath)surrogate
The conductance catheter method accurately estimates left ventricular volume changes in isolated canine hearts, providing a signal proportional to actual volume.
Cite This Study
Burkhoff et al. (1985) studied this question.