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November 18, 1988Science

An Early Hierarchic Role of U1 Small Nuclear Ribonucleoprotein in Spliceosome Assembly

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Population

yeast in vitro splicing system

Design

Preclinical

Authors

SRStephanie W. RubyCalifornia Institute of TechnologyJAJohn AbelsonFlorida State University

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Overview

Hypothesis-generating for spliceosome assembly; leaves open translation to human cardiovascular splicing disorders.

Structured PICO

P
Population
yeast in vitro splicing system
I
Intervention
new affinity purification method for the spliceosome
O
Outcome
insight into the very early stages of spliceosome formation

Demonstrates that U1 snRNP mediates the early interaction of the two splice site regions during spliceosome formation in yeast.

Cite This Study

Ruby et al. (1988) studied this question.

synapsesocial.com/papers/6a6f9a6884cc45bb7bdfa4behttps://doi.org/10.1126/science.2973660
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein.1988 · 189 citations
  2. 2U2 RNA from yeast is unexpectedly large and contains homology to vertebrate U4, U5, and U6 small nuclear RNAs1986 · 161 citations
  3. 3PRE-mRNA SPLICING1986 · 675 citations