U1 Small Nuclear Ribonucleoproteins are Required Early During Spliceosome Assembly

View Full Paper

Ask AI

Bookmark

Population

in vitro splicing model (pre-mRNA and U1 snRNPs)

Design

Preclinical

Authors

Discussion

U1 snRNP depletion impairs spliceosome assembly in animal models; hypothesis-generating for splicing therapies but should not change practice.

Population

in vitro splicing model (pre-mRNA and U1 snRNPs)

Intervention

Removal of 5' terminal sequences of U1 RNA or removal of U1 snRNPs

Outcome

Spliceosome assembly and association of snRNPs with precursor RNA

U1 snRNPs participate in the early recognition of substrate RNAs by U2 to U6 snRNPs during spliceosome assembly.

Zillmann et al. (1987) studied this question.

View Full Paper

Ask AI

Bookmark

U1 snRNP depletion impairs spliceosome assembly in animal models; hypothesis-generating for splicing therapies but should not change practice.