Why the study?
The mechanisms underlying changes in immune cells during CAD and MI, including potential dysregulation of intracellular signaling pathways, remain poorly understood.
Does transcriptome profiling of PBMCs identify a diagnostic signature for myocardial infarction?
Population
MI patients and controls
Comparison
MI patients vs controls
Design
Transcriptome profiling and machine learning study with validation on two independent open GEO datasets
Authors
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A 5-gene PBMC signature classifies MI (ROC 0.911); leaves open diagnostic utility pending larger prospective validation.
Does transcriptome profiling of PBMCs identify a diagnostic signature for myocardial infarction?
A 5-gene transcriptional signature from peripheral blood mononuclear cells can accurately distinguish patients with myocardial infarction from healthy controls.
Osmak et al. (2020) studied this question.
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