Population
Vertebrate filamins (FLNs) protein structures
Design
Preclinical
Authors
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Novel filamin domain organization requires cellular and in vivo validation; leaves open effects on platelet adhesion or cardiovascular therapies.
The study reveals a novel structural organization in the N-terminal region of filamins, where domain 5 stabilizes domain 4 to regulate its interaction with ligands like platelet glycoprotein Ib.
Sethi et al. (2014) studied this question.
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