Population
Filamin A mechanosensor domain pair 20-21 (IgFLNa20-21)
Comparison
Binding of adaptor protein migfilin-derived… vs Absence of interacting peptide (unbound state)
Design
Preclinical
Authors
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Filamin A domain flexibility may influence cardiomyocyte mechanosensing; leaves open any role in remodeling or therapy.
The binding of interacting peptides induces conformational changes in the Filamin A mechanosensor domain pair 20-21, which may play a role in its mechanosensor function.
Seppälä et al. (2015) studied this question.
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