May 30, 2001FEBS LettersOpen Access

Mechanical unfolding of single filamin A (ABP‐280) molecules detected by atomic force microscopy

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Population

Single filamin A (ABP-280) molecules

Design

Preclinical

Authors

Discussion

Supports filamin A extensibility in cytoskeletal models; leaves open in vivo validation and cardiovascular relevance.

Population

Single filamin A (ABP-280) molecules

Intervention

Mechanical pulling using atomic force microscopy at a speed of 0.37 microm/s

Outcome

Mechanical properties including unfolding interval, unfolding force, and reversibility

Single filamin A molecules exhibit reversible mechanical unfolding of their Ig-fold domains, endowing the protein with great extensibility.

Furuike et al. (2001) studied this question.

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