Tropomyosin is localized in cytoplasmic fibers in mouse embryo fibroblasts, similar to actin.
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No clinical implications from this animal model; leaves open tropomyosin function in human cytoskeletal dynamics.
Antiserum to chick skeletal muscle tropomyosin was used to localize tropomyosin in mouse embryo fibroblasts by the indirect fluorescein labeled antibody technique. Specific staining was observed cytoplasmic fibers, which extended out into the cell processes. The staining pattern in these cells is similar to that previously described by others for actin. This observation suggests that in fibroblasts tropomyosin, like actin, is localized in fibers in the cytoplasm.
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Jorgensen et al. (1975) studied this question.
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