Population
Cultured nonmuscle cells (chicken embryo fibroblast [CEF] cells and human bladder carcinoma [EJ] cells)
Design
Preclinical
Authors
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Hypothesis-generating for cytoskeletal regulation in migrating cells; leaves open isoform roles in cardiac remodeling.
Lower molecular mass isoforms of tropomyosin are uniquely localized in ruffling membranes of nonmuscle cells, suggesting a role in regulating microfilament stability and cell motility.
Hegmann et al. (1988) studied this question.
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