What does this research mean for the field?

The five isoforms of tropomyosin in rat cultured cells can be classified into high and low molecular weight groups, with the low molecular weight isoforms exhibiting reduced head-to-tail polymerization and lower actin affinity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1985Journal of Biological ChemistryOpen Access

Purification and characterization of multiple isoforms of tropomyosin from rat cultured cells.

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Population

Rat cultured cells

Design

Preclinical

Authors

FMFumio MatsumuraRutgers, The State University of New Jersey SYShigeko YamashiroRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Low-Mr tropomyosin properties may underlie cytoskeletal changes in transformed cells; hypothesis-generating for isoform-specific actin regulation in disease models.

Structured PICO

Population

Rat cultured cells

Intervention

Purification and partial separation of multiple isoforms of tropomyosin by chromatography on hydroxylapatite

Outcome

Characterization of tropomyosin isoforms (structural and immunological analyses, head-to-tail polymerization, affinity to actin)

Tropomyosin isoforms in rat cultured cells differ in their ability for head-to-tail polymerization and actin affinity, which may relate to microfilament organization changes in transformed cells.

Cite This Study

Matsumura et al. (1985) studied this question.

synapsesocial.com/papers/6a1df01d79ea62caf660487b https://doi.org/10.1016/s0021-9258(17)38803-8

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Implication

Low-Mr tropomyosin properties may underlie cytoskeletal changes in transformed cells; hypothesis-generating for isoform-specific actin regulation in disease models.

Purification and characterization of multiple isoforms of tropomyosin from rat cultured cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Purification and characterization of multiple isoforms of tropomyosin from rat cultured cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider