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October 24, 2006Blood

SSEA-4 identifies mesenchymal stem cells from bone marrow

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Authors

EGEun Ji GangUniversity of Southern CaliforniaDBDarko BosnakovskiUniversity of MinnesotaCFCamila Alexandrina FigueiredoUniversidade Federal da Bahia

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Implication

Laboratory study demonstrates SSEA-4 expression on bone marrow mesenchymal stem cells, indicating a viable marker for prospective cell isolation in regenerative medicine.

Key Points

  • To identify a reliable surface marker for the prospective isolation and biological characterization of adult bone marrow mesenchymal stem cells.
  • Screened adult bone marrow nonhematopoietic stromal cell populations for the presence of embryonic surface markers.
  • Evaluated the capacity of stage-specific embryonic antigen-4 (SSEA-4) to isolate cells capable of multilineage differentiation.
  • Identified SSEA-4, an early embryonic glycolipid antigen, as an adult bone marrow mesenchymal stem cell marker.
  • Demonstrated that SSEA-4 marks the multipotent stromal population that differentiates into bone, cartilage, and fat lineages.

Cite This Study

Gang et al. (2006) studied this question.

synapsesocial.com/papers/6a6f9dc775498292b708fe53https://doi.org/10.1182/blood-2005-11-010504
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Also Consider

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  1. 1Preimplantation Human Embryos and Embryonic Stem Cells Show Comparable Expression of Stage‐Specific Embryonic Antigens2002 · 485 citations
  2. 2Donor variation in the growth properties and osteogenic potential of human marrow stromal cells1999 · 509 citations
  3. 3Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model2000 · 1,026 citations
  4. 4Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-11991 · 88 citations