Why the study?
Does renal denervation improve baroreflex regulation of renal sympathetic nerve activity and heart rate in obese rats?
Population
Sprague Dawley rats fed a high-fat diet (45% kcal) or normal diet (12% kcal) for 60 days to induce obesity
Comparison
Bilateral renal denervation vs Intact renal nerves
Design
Preclinical
Follow-up
60 days
Authors
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Obesity-induced baroreflex impairment requires intact renal nerves in rats; leaves open translation to human hypertension therapy.
Does renal denervation improve baroreflex regulation of renal sympathetic nerve activity and heart rate in obese rats?
High-fat diet-induced obesity causes hypertension and dysregulation of baroreflexes that is dependent on intact renal innervation, highlighting the role of renal neural signals in autonomic derangement.
Khan et al. (2015) studied this question.
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