Why the study?
Does disease remission improve carotid artery stiffness and metabolic markers of atherosclerosis in patients with Cushing's disease?
Population
25 patients with Cushing's disease, 32 sex- and age-matched subjects, and 32 body mass index-matched subjects.
Comparison
Disease remission vs Active disease state and healthy controls
Design
Cohort
Follow-up
1 year after remission
Authors
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Remission improves but does not normalize vascular and metabolic markers in Cushing's disease; leaves open whether longer follow-up reduces residual CV risk.
Does disease remission improve carotid artery stiffness and metabolic markers of atherosclerosis in patients with Cushing's disease?
Patients with Cushing's disease have severe atherosclerotic damage that improves but does not fully normalize 1 year after disease remission, leaving them at high cardiovascular risk.
Faggiano et al. (2003) studied this question.