Key result
Cushing syndrome was associated with increased carotid intima-media thickness and a higher prevalence of carotid plaques compared to essential hypertension and healthy subjects.
Why the study?
Does Cushing syndrome increase subclinical atherosclerosis (measured by cIMT and ABI) compared to essential hypertension and healthy subjects?
Cross-Sectional (n=95)
No
Does Cushing syndrome increase subclinical atherosclerosis (measured by cIMT and ABI) compared to essential hypertension and healthy subjects?
Answers are grounded in this paper and cite their sources.
Cushing syndrome is associated with increased subclinical atherosclerosis, as evidenced by increased carotid intima-media thickness and a higher prevalence of pathological ankle-brachial index compared to essential hypertension and healthy controls.
BACKGROUND: Cushing syndrome (CS) has been described as a killing disease due its cardiovascular complications. In fact, chronic cortisol excess leads to a constellation of complications, including hypertension, hyperglycemia, adiposity, and thromboembolism. The main vascular alteration associated with CS is atherosclerosis. METHODS: Aim of this study was to analyze carotid intima-media thickness (cIMT) and ankle-brachial index (ABI), two surrogate markers of subclinical atherosclerosis in a consecutive series of CS patients, compared to patients with essential hypertension (EH) and health subjects (HS). RESULTS: Patients with CS showed a significant increase (P<0.05) of cIMT (0.89±0.17 mm) compared to EH (0.81±0.16 mm) and HS (0.75±0.4 mm), with a high prevalence of plaque (23%; P<0.03). Moreover, CS patients showed a mean ABI values (1.07±0.02) significantly lower respect to HS (1.12±0.11; P<0.05), and a higher percentage (20%) of pathological values of ABI (≤0.9; P<0.03). CONCLUSION: In conclusion, we confirmed and extended the data of cIMT in CS, and showed that the ABI represent another surrogate marker of subclinical atherosclerosis in this disease.
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Petramala et al. (2015) conducted a cross-sectional in Cushing syndrome (n=95). Cushing syndrome vs. Essential hypertension and healthy subjects was evaluated on Carotid intima-media thickness (cIMT) (p=<0.05). Cushing syndrome was associated with increased carotid intima-media thickness and a higher prevalence of carotid plaques compared to essential hypertension and healthy subjects.
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