Why the study?
Does Astragalus polysaccharide suppress doxorubicin-induced cardiotoxicity?
Population
Cancer patients who underwent doxorubicin chemotherapy, doxorubicin-induced neonatal rat cardiomyocyte…
Comparison
Astragalus polysaccharide (APS) vs Doxorubicin treatment without APS
Design
Preclinical
Authors
Loading...
Hypothesis-generating for APS against doxorubicin cardiotoxicity; leaves open clinical translation pending human studies.
Does Astragalus polysaccharide suppress doxorubicin-induced cardiotoxicity?
Astragalus polysaccharide demonstrates protective effects against doxorubicin-induced cardiotoxicity by suppressing oxidative stress and apoptosis via regulation of the PI3k/Akt and p38MAPK pathways.
Cao et al. (2014) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: