An Update on Floating Drug Delivery System: A Review

The oral route is the most appropriate and widely used for the delivery of drugs to the systemic circulation. This route has high acceptability for patients, particularly due to the ease of administration. Over the years, oral dosage forms have become increasingly world-wise in the pharmaceutical field, with controlled release drug delivery systems that release the drug at a predetermined rate playing a major role. Various approaches have been designed and utilized to achieve efficient drug delivery for those drugs that have poor bioavailability and shorter gastric residence time. On the other hand floating drug delivery system, one of the most extensively used approaches of the Gastro retentive drug delivery system has an advantage for the drugs that are absorbed primarily in the upper segments of the Gastrointestinal tract i.e., stomach, duodenum, and jejunum. The main purpose of writing this review article is to emphasize the types of floating drug delivery systems, the principle, and mechanism of floating action to achieve gastric retention. This review also outlines the In-vitro and In-vivo studies used to evaluate the potential, performance, and application of floating systems in to overcome various problems encountered during the development of a dosage form.