Controlled release tablets consisting of theophylline, dried molasses, and hydroxypropylmethyl cellulose was prepared by the process of direct compression. The release mechanism was shown to be by diffusion control. However, first-order kinetics also appeared to describe the release process. The release rate constant in various media was in the rank order of intestinal fluid > gastric fluid > distilled water, and was found to be independent of both tablet hardness and drug concentration. Experimental formulations compared well with commercial products, and met the USP proposed standards for controlled release products.
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Uko-nne et al. (1989) studied this question.