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To review major NAD+ biosynthesis routes, highlight factors governing NAD+ homeostasis in Saccharomyces cerevisiae, and discuss their implications for human disease therapies.

February 19, 2020BiomoleculesOpen Access

NAD+ Metabolism and Regulation: Lessons From Yeast

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To review major NAD+ biosynthesis routes, highlight factors governing NAD+ homeostasis in Saccharomyces cerevisiae, and discuss their implications for human disease therapies.
Literature synthesis of genetic and biochemical investigations utilizing the budding yeast Saccharomyces cerevisiae.
Evaluation of conserved NAD+ biosynthesis pathways, nutrient-sensing networks, and interconnected precursor regulation.
Three primary NAD+ biosynthesis pathways maintain cellular pools and are structurally conserved from bacteria to humans.
Novel homeostatic regulators identified in yeast coordinate cellular NAD+ distribution across distinct metabolic and nutrient-sensing signaling states.
Dysregulated NAD+ homeostasis correlates with human pathologies including diabetes, cancer, and neurodegeneration, identifying precursor pathways as targeted therapeutic opportunities.

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Implication

Mechanistic review reveals pathways of NAD+ biosynthesis and regulation in yeast, highlighting therapeutic targets for human metabolic and degenerative disorders.

Cite This Study

Croft et al. (2020) studied this question.

synapsesocial.com/papers/6a6fa8b531a3df824327fe3a https://doi.org/10.3390/biom10020330

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Implication

Mechanistic review reveals pathways of NAD+ biosynthesis and regulation in yeast, highlighting therapeutic targets for human metabolic and degenerative disorders.

NAD+ Metabolism and Regulation: Lessons From Yeast

Key Points

Discussion

Implication

Cite This Study

NAD+ Metabolism and Regulation: Lessons From Yeast

Key Points

Discussion

Implication

Cite This Study

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