Why the study?
Does combined DTP-killed poliovirus vaccine improve poliovirus antibody detection in infants in West Africa compared to DTP vaccine alone?
Population
Subjects two to eight months old at the start of the study in a rural area of Senegal.
Comparison
Combined diphtheria-tetanus-pertussis-killed… vs DTP vaccine without poliovirus vaccine in a…
Design
Cohort
Follow-up
Six months after the second dose
Authors
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Supports higher seropositivity with combined DTP-IPV in West African infants; leaves open impact on clinical poliomyelitis outcomes.
Does combined DTP-killed poliovirus vaccine improve poliovirus antibody detection in infants in West Africa compared to DTP vaccine alone?
A routine immunization program using killed poliovirus vaccine in West Africa resulted in high rates of seroconversion and a reduction in paralytic poliomyelitis cases.
Stoeckel et al. (1984) studied this question.
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