Why the study?
Does apoE genotype associate with dementia, cerebrovascular disease, and mortality in 85-year-old people?
Population
412 people aged 85 years (303 non-demented, 109 demented) from a population-based sample
Comparison
apoE epsilon4 allele and epsilon2 allele carrier… vs Non-carriers of the respective apoE alleles
Design
Cohort
Follow-up
3 years (between ages 85 and 88)
Authors
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apoE4 carriers with lesions face higher dementia risk at 85; leaves open interaction effects in prospective cohorts.
Does apoE genotype associate with dementia, cerebrovascular disease, and mortality in 85-year-old people?
The apoE epsilon4 allele significantly increases the risk of dementia in 85-year-olds only when accompanied by ischaemic white matter lesions.
Skoog et al. (1998) studied this question.
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