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Synthesize technological advancements in glycan microarrays and review their applications in mapping the specificity of mammalian and microbial glycan-binding proteins.

March 3, 2011Annual Review of Biochemistry

Glycan Microarrays for Decoding the Glycome

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Synthesize technological advancements in glycan microarrays and review their applications in mapping the specificity of mammalian and microbial glycan-binding proteins.
Reviewed chip-based fabrication techniques utilizing diverse glycan libraries designed to represent the human glycome.
Assessed functional screening assays tracking glycan-binding protein interactions across host-pathogen biology, immunology, and oncology.
Glycan microarrays enable high-throughput characterization of diverse glycan-binding proteins governing normal physiology and pathogenesis.
Chip platforms resolve specific binding profiles essential for understanding host-pathogen interactions and identifying targets for vaccines and cancer antigens.

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Implication

Review demonstrates advances in glycan microarray platforms for profiling glycan-binding proteins, highlighting key applications in host-pathogen biology and oncology.

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Rillahan et al. (2011) studied this question.

synapsesocial.com/papers/6a6faa3d6c240de38cdb8b6e https://doi.org/10.1146/annurev-biochem-061809-152236

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Implication

Review demonstrates advances in glycan microarray platforms for profiling glycan-binding proteins, highlighting key applications in host-pathogen biology and oncology.

Glycan Microarrays for Decoding the Glycome

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Discussion

Implication

Cite This Study

Glycan Microarrays for Decoding the Glycome

Key Points

Discussion

Implication

Cite This Study

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