April 15, 2015Lipids in Health and DiseaseOpen Access

The role of plasma triglyceride/high-density lipoprotein cholesterol ratio to predict cardiovascular outcomes in chronic kidney disease

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Why the study?

Does the TG/HDL-C ratio predict cardiovascular outcomes in patients with chronic kidney disease?

Population

197 patients with chronic kidney disease Stages 1 to 5, mean age 53±12 years, 51% male. Patients taking ACE…

Design

Cohort

Follow-up

mean 30 (range 9 to 35) months

Authors

ASAlper SönmezGüven Hospital MYMahmut İlker YılmazGeneral / Preventive / Lipids MSMutlu SağlamHacettepe University

Discussion

Member takes

Implication

May aid CKD cardiovascular risk stratification; leaves open whether ratio modification improves outcomes.

Structured PICO

Does the TG/HDL-C ratio predict cardiovascular outcomes in patients with chronic kidney disease?

Population

197 patients with chronic kidney disease (CKD) Stages 1 to 5, mean age 53±12 years, 51% male. Patients taking ACE inhibitors, ARBs, statins, EPO, or supplemental vitamin pills were excluded.

Intervention

Plasma triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio (evaluated as an observational predictor)

Outcome

Composite of fatal and non-fatal cardiovascular events (stroke, myocardial infarction, complications of peripheral vascular disease, aneurysm rupture, or cardiovascular death)composite

An elevated TG/HDL-C ratio is an independent predictor of poor cardiovascular outcomes and endothelial dysfunction in patients with chronic kidney disease.

Limitations

HOMA-IR levels were not different between groups, possibly because the HOMA index is only a rough estimate of insulin sensitivity
Observational nature of the study
Relatively small number of patients
Substantial amount of subjects lost to follow up
Lower than expected incidence of CV events due to inclusion of CKD-1 and CKD-2 subjects
Exclusion of patients treated with ACEIs, ARBs, or statins makes the cohort not completely representative of the adult CKD population

Cite This Study

Sönmez et al. (2015) studied this question.

synapsesocial.com/papers/6a6fabd226a7f98052dc49f4 https://doi.org/10.1186/s12944-015-0031-4

Topics

Women and heart disease Sermorelin

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The role of plasma triglyceride/high-density lipoprotein cholesterol ratio to predict cardiovascular outcomes in chronic kidney disease

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

The role of plasma triglyceride/high-density lipoprotein cholesterol ratio to predict cardiovascular outcomes in chronic kidney disease

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider