Why the study?
Does the combination of sofosbuvir and amiodarone disrupt cellular electrophysiology and calcium handling in hiPSC-CMs compared to either drug alone?
Does the combination of sofosbuvir and amiodarone disrupt cellular electrophysiology and calcium handling in hiPSC-CMs compared to either drug alone?
hiPSC-CMs can successfully model the clinically observed cardioactive pharmacodynamic drug-drug interaction between sofosbuvir and amiodarone, demonstrating disruption of intracellular calcium handling and electrophysiology.
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Supports mechanistic interaction on cardiomyocytes; leaves open clinical translation and need for prospective confirmation.
Millard et al. (2016) studied this question.
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